Ylang-ylang mafuta

Ylang-ylangmafuta anokosha (YEO), anowanikwa kubva mumaruva emuti wemunzvimbo dzinopisaCanangaodorataHook. f. & Thomson (mhuriAnnonaceae), yakashandiswa zvakanyanya mukurapa kwechinyakare nekushandiswa kwakawanda, kusanganisira kufunganya uye kuchinjwa neuronal states. Neuropathic kurwadziwa chirwere chisingaperi chine chiitiko chepamusoro che comorbidities, zvakadai sekuzvidya mwoyo, kuora mwoyo, nezvimwe zvirwere zvepfungwa, izvo zvinokanganisa zvakanyanya hupenyu hwemurwere. Mishonga iripo iye zvino inoshandiswa pakutarisira kurwadziwa kweuropathic haina kukwana nekuda kwekushaya simba uye kushivirira, kuratidza kudiwa kwemishonga ye pharmacotherapy iri nani. Tsvakurudzo dzinoverengeka dzekiriniki dzakashuma kuti masaja kana kufemerwa nemafuta akakosha akasarudzwa kunoderedza zviratidzo zvine chekuita nekurwadziwa uye kufunganya.

Chinangwa chechidzidzo ichi chaive chekuongorora analgesic properties yeYEOuye kushanda kwayo mukuderedza neuropathy-yakabatana nekuchinja kwemaitiro.

Iyo analgesic zvivakwa zvakaedzwa mune yakachengetedzwa nerve yekukuvara modhi uchishandisa mbeva dzechirume. Anxiolytic, antidepressant, uye locomotor zvivakwa zvakaongororwawo uchishandisa maitiro ebvunzo. Pakupedzisira, iyo YEO maitiro echiito akaongororwa mumusana uye hippocampus yeuropathic mice.

Oral administration yeYEO(30 mg / kg) yakaderedza SNI-induced neuropathic marwadzo uye inogadzirisa zviratidzo zvekuzvidya mwoyo zvine chokuita nekurwadziwa zvakaonekwa mazuva 28 mushure mekuvhiyiwa.YEOyakaderedza kutaura kweMAPKs, NOS2, p-p65, mamaki euroinflammation, uye akakurudzira normalizing maitiro pamazinga eurotrophin.

YEOinduced neuropathic pain relief uye yakagadziridzwa marwadzo-akabatanidzwa kufunganya, anomiririra anonakidza mukwikwidzi wekutarisira mamiriro ekurwadziwa kweuropathic uye marwadzo ane chekuita necomorbidities.