OEM Tsika Package Natural Macrocephalae Rhizoma mafuta

tsananguro pfupi:

Semushonga unoshanda wekemotherapeutic, 5-fluorouracil (5-FU) inoshandiswa zvakanyanya pakurapa mamota anouraya mudumbu remudumbu, musoro, mutsipa, chifuva, uye ovary. Uye 5-FU ndiyo yekutanga-mutsara mushonga we colorectal cancer mukiriniki. Iyo yekuita maitiro e5-FU ndeyekuvhara shanduko yeuracil nucleic acid kuita thymine nucleic acid mumasero emudumbu, zvobva zvakanganisa synthesis uye kugadzirisa kweDNA neRNA kuti iite cytotoxic mhedzisiro (Afzal et al., 2009; Ducreux et. al., 2015; Longley et al., 2003). Nekudaro, 5-FU inogadzirawo chemotherapy-induced diarrhea (CID), imwe yeakajairika maitiro akashata anotambudza varwere vazhinji (Filho et al., 2016). Chiitiko chechirwere chechirwere muvarwere vanobatwa ne5-FU chakasvika ku50% -80%, iyo yakakanganisa zvakanyanya kufambira mberi uye kushanda kwekemotherapy (Iacovelli et al., 2014; Rosenoff et al., 2006). Nekuda kweizvozvo, zvakakosha zvakakosha kuwana kurapa kunoshanda kwe5-FU induced CID.

Parizvino, kupindira kusina zvinodhaka uye kupindira kwezvinodhaka zvakaendeswa kune kliniki kurapwa kweCID. Kupindira kusina zvinodhaka kunosanganisira kudya kwakanaka, uye kuwedzera nemunyu, shuga nezvimwe zvinovaka muviri. Zvinodhaka senge loperamide uye octreotide zvinowanzoshandiswa mukurwisa-manyoka kurapa kweCID (Benson et al., 2004). Pamusoro pezvo, ethnomedicines inotambirwawo kurapa CID neyavo yakasarudzika kurapa munyika dzakasiyana. Traditional Chinese mushonga (TCM) imwe yakajairika ethnomedicine yave ichiitwa kwemakore anopfuura 2000 munyika dzeEast Asia dzinosanganisira China, Japan neKorea (Qi et al., 2010). TCM inobata kuti chemotherapeutic mishonga inogona kukonzera Qi kushandiswa, kushomeka kwespleen, mudumbu kusagadzikana uye endophytic kunyorova, zvichikonzera kusashanda zvakanaka kwematumbo. Muchidzidzo cheTCM, nzira yekurapa yeCID inofanira kunyanya kuenderana nekuwedzera Qi uye kusimbisa spleen (Wang et al., 1994).

Midzi yakaomeswa yeAtractylodes macrocephalaKoidz. (AM) uyePanax ginsengCA Mey. (PG) ndiyo yakajairika mishonga yemakwenzi muTCM ine mhedzisiro yakafanana yekuwedzera Qi uye kusimbisa spleen (Li et al., 2014). AM uye PG zvinowanzo shandiswa senge herb pair (iyo yakapusa yeChinese herbal kuenderana) nemhedzisiro yekuwedzera Qi uye kusimbisa spleen kurapa manyoka. Semuenzaniso, AM uye PG zvakanyorwa mumhando dzekare dzekurwisa manyoka seShen Ling Bai Zhu San, Si Jun Zi Tang kubva.Taiping Huimin Heji Ju Fang(Rwiyo rwedzinza, China) uye Bu Zhong Yi Qi Tang kubvaPi Wei Lun(Yuan Dynasty, China) (Mufananidzo 1). Zvidzidzo zvinoverengeka zvakapfuura zvakataura kuti ese matatu mafomula ane kugona kudzikisa CID (Bai et al., 2017; Chen et al., 2019; Gou et al., 2016). Pamusoro pezvo, ongororo yedu yapfuura yakaratidza kuti Shenzhu Capsule inongove ne AM uye PG ine zvinogona kuitika pakurapa manyoka, colitis (xiexie syndrome), uye zvimwe zvirwere zvemudumbu (Feng et al., 2018). Nekudaro, hapana chidzidzo chakakurukura nezve maitiro uye maitiro e AM nePG mukurapa CID, ingave musanganiswa kana yega.

Ikozvino gut microbiota inoonekwa sechinhu chinogona kuita mukunzwisisa nzira yekurapa yeTCM (Feng et al., 2019). Zvidzidzo zvemazuva ano zvinoratidza kuti gut microbiota inoita basa rakakosha mukuchengetedza intestinal homeostasis. Hutano gut microbiota inobatsira mudumbu mucosal kudzivirira, metabolism, immune homeostasis uye mhinduro, uye pathogen kudzvinyirira (Thursby naJuge, 2017; Pickard et al., 2017). Disordered gut microbiota inokanganisa mashandiro emuviri uye immune yemuviri wemunhu zvakananga kana zvisina kunanga, zvichikonzera maitiro eparutivi semanyoka (Patel et al., 2016; Zhao naShen, 2010). Tsvagiridzo dzakaratidza kuti 5-FU yakashandura zvinoshamisa chimiro chegut microbiota mumanyoka mbeva (Li et al., 2017). Naizvozvo, mhedzisiro ye AM uye PM pa5-FU yakakonzera manyoka inogona kuyananidzwa negut microbiota. Nekudaro, ingave AM nePG chete uye musanganiswa inogona kudzivirira 5-FU yakakonzera manyoka nemodulating gut microbiota haisati yazivikanwa.

Kuti tiongorore maitiro ekurwisa-manyoka uye maitiro ari pasi pe AM nePG, takashandisa 5-FU kutevedzera manyoka emakonzo. Pano, takatarisa pane zvingangoitika zveiyo imwechete uye yakasanganiswa manejimendi (AP) yeAtractylodes macrocephalamafuta anokosha (AMO) uyePanax ginsengyakazara saponins (PGS), iyo inoshanda zvikamu zvakateerana zvakatorwa kubva ku AM uye PG, pane manyoka, intestinal pathology uye microbial chimiro mushure me5-FU chemotherapy.