Mutengo wekutengesa wakawanda 100% Pure Forsythiae Fructus mafuta Relax Aromatherapy Eucalyptus globulus

Mutengo mukuru 100% Pure Forsythiae Fructus oil Relax Aromatherapy Eucalyptus globulus Featured Image

tsananguro pfupi:

Forsythia suspensa(Thunb.) Vahl. (Mhuri Oleaceae) is ornamental shrub, michero yacho inoshandiswa seTCM inozivikanwa "Forsythiae Fructus" (FF) (连翘in Chinese). Iwo maitiro eTCM eFF anopfupikiswa seanovava mukuravira, ane nyoro inotonhora hunhu uye mapapu, moyo kana intestinum meridian kugoverwa (Pharmacopoeia Commission yePRC, 2015), hunhu uhwo hunofanana nekuratidzwa kweanti-kuzvimba TCM, maererano naChen. uye Zhang (2014). MuShennong's herbal, FF yakashandiswa pakurapa pyrexia, kuzvimba, gonorrhea, carbuncle uye erysipelas (Cho et al., 2011). Mhando mbiri dzeFF dziripo, muchero wakaibva wakasvibira unonzi "Qingqiao" uye yero yakaibva zvakazara inonzi "Laoqiao". Ose ari maviri anoshanda sezviri pamutemo masosi eFF, zvisinei, Qingqiao inoshandiswa kakawanda muTCM mishonga (Jia et al., 2015). Nzvimbo huru dzinogadzira dzeFF iHebei, Shaanxi, Shanxi, Shandong, Anhui, Henan, Hubei, Jiangsu (yakarimwa) uye Sichuan Mapurovhinzi (Editorial Board of Flora yeChina, 1978).

Muchinyorwa cha2015 Chinese Pharmacopoeia, 114 Chinese mishonga yekugadzirira ine FF yakanyorwa, yakadai seShuanghuanglian oral solution, Yinqiao Jiedu tablet, Niuhuang Shangqing mapiritsi, etc (Pharmacopoeia Commission yePRC, 2015). Tsvagiridzo dzemazuva ano dzinoratidza dzinopesana nekuputika (Kim et al., 2003), antioxidant (CC Chen et al., 1999), antibacterial (Han et al., 2012), anti-cancer (Hu et al., 2007), anti -virus (Ko et al., 2005), anti-allergies (Hao et al., 2010), neuroprotective (S. Zhang et al., 2015) mhedzisiro,etc.Kunyange zvazvo michero chete inoshandiswa seTCM, zvimwe zvidzidzo zvakashuma phytochemistry uye pharmacological migumisiro yemashizha (Ge et al., 2015, Zhang et al., 2015), maruva (Takizawa et al., 1981) uye mbeu (Zhang et al. ., 2002) yeF. suspensa. Naizvozvo, isu zvino tinopa tarisiro yakarongeka yeruzivo rwuripo rweF. suspensa, kusanganisira kushandiswa kwechinyakare, botany, phytochemistry, pharmacology, toxicity, pharmacokinetics uye kutonga kwemhando. Zvakare, nzira dzinobvira dzenguva yemberi dzetsvagurudzo dzinokurukurwa.

Zvidimbu zvechikamu

Mashandisirwo echivanhu

Mune classical Chinese herbal texts, FF yakanyorwa seyakakosha mukurapa rat fistula, scrofula, carbuncle, chironda chakaipa, gall tumor, kupisa uye chepfu (Shennong's herbal, Bencao Chongyuan, Bencao Zhengyi, Zhenglei Bencao). Zvinoenderana neakawanda ekare ekare, iyi herb yekurapa inoshanda zvakanyanya pakubvisa kupisa kwemoyo chiteshi uye kuburitsa kunyorova-kupisa kwespleen nemudumbu. Iyo zvakare inorapa pakurapa stranguria, edema, qi stagnancy uye ropa stasis.

Botany

F. suspensa(Kuchema Forsythia) is ornamental deciduous shrub inowanikwa kuChina, inokura kusvika kureba hunosvika mamita matatu (Fig. 1). Ine mhango internodes ane akapararira kana pendulous mapazi ane yellow-brown kana grey-brown muruvara. Mashizha anowanzo nyore, asi dzimwe nguva 3-foliolate. Mashizha ane ovate, akafaranuka ovate, kana elliptic-ovate uye 2–10 × 1.5–5 cm2 muhukuru ane hwaro hwakatenderedzwa kune cuneate uye acute apex. Mativi ese maviri emashizha akasvibira, anopenya nekupinza kana kukora

Phytochemistry

Mazuva ano, 237 makomisheni akawanikwa mukatiF. suspensa, kusanganisira 46 lignans (1-46), 31 phenylethanoid glycosides (47-77), 11 flavonoids (78-88), 80 terpenoids (89-168), 20 cyclohexylethanol derivatives (169-188), alkaloids matanhatu (1918) ), mana steroidal (195-198) uye 39 mamwe macommunication (199-237). Pakati pavo, zvikamu zviviri (21-22) zvakaparadzaniswa nemaruva eF. suspensa, 19 zvikamu (94–100, 107–111, 115–117, 198, 233–235) zvakaparadzaniswa nemashizha eF. suspensa, zvikamu zvina

Anti-inflammatory effects

Anti-kuzvimba zviitiko zveFF zvinotsigira kupisa-kuchenesa mhedzisiro (Guo et al., 2015). Kuzvimba ndiko kupindura kwemuviri kune kutapukira, allergic, kana makemikari kukurudzira (Lee et al., 2011). Inobata mukukura kwezvirwere zvisingaperi, zvakadai sezvirwere zveganda, allergies, uye kenza,etc.FF ndeimwe yeTCM ine simba rekurwisa-kuzvimba masimba, inoshandiswa zvakanyanya kune kusingaperi uye kwakanyanya kuzvimba. Iwo ekurwisa-kuzvimba zviitiko zveFF akaiswa pamusoro mashanu pakati pe81 akaedzwa TCM (70% ethanol

Muchetura

Kusvika ikozvino, hapana chirevo pamusoro pehupfu hweFF. Daily administration dose yeFF inofungidzirwa kuva 6-15 g (Pharmacopoeia Commission yePRC, 2015). Mishumo yakakodzera yakaratidza kuti hapana huturu hwemvura kana ethanol inotorwa pamashizha eF. suspensamumakonzo, kunyangwe pamutengo wezuva nezuva we61.60 g/kg (Ai et al., 2011, Hou et al., 2016, Li et al., 2013). Han et al. (2017) yakashuma kuti hapana huturu hwephillyrin (kubva pamashizha eF. suspensa)muNIH mbeva (18.1 g/kg/zuva, po, kwemazuva gumi nemana) kana kwete

Pharmacokinetics

Li et al. yakaratidza mapfumbamwe chikamu I metabolites ye phillyrin mune urinary samples yemakonzo uye yakaratidza nzira dzayo dzinogona kuita metabolic mumakonzo. Phillyrin yakatanga hydrolyzed kuita phillygenin ndokuzoshandurwa kune mamwe metabolites zvakanyanya kuburikidza nemethylation, demethylation, dehydroxylation uye ring-kuvhura maitiro (Li et al., 2014c). H. Wang nevamwe. (2016) yakaratidza 34 chikamu I uye chikamu II metabolites yephillyrin uye yakaratidza kuti hydrolysis, oxidation uye sulfation yakanga yakakura.

Kudzora kwehutano

Kudzora mhando yeFF, iyo Chinese Pharmacopoeia inoratidzira morphological, microscopic uye TLC kuzivikanwa mukuwedzera kune HPLC kutsunga. Akakodzera FF samples anofanirwa kunge aine anopfuura 0.150% phillyrin (Pharmacopoeia Commission yePRC, 2015).

Zvakadaro, chicherechedzo chimwechete chehuwandu, phillyrin, chinoita sechisina kukwana kuongorora kunaka kweFF. Munguva pfupi yapfuura, akasiyana bioactive zvikamu muFF akaongororwa neakasarudzika chromatography, electrophoresis, MS uye NMR nzira, senge.

Mhedziso uye maonero emangwana

Ongororo yezvino inopfupikisa ruzivo rwakakwana nezve mashandisirwo echinyakare, botany, phytochemistry, mishonga yemhedzisiro, chepfu, pharmacokinetics uye kutonga kwemhando.F. suspensa. Muzvinyorwa zvekare zveChinese herbal uye Chinese Pharmacopoeia, FF inonyanya kushandiswa pakupisa-kuchenesa uye kubvisa huturu. Kusvika ikozvino, anopfuura mazana maviri nemakumi matatu emakomisheni akaparadzaniswa uye akaonekwa kubva mumuti uyu. Pakati pavo, lignans uye phenylethanoid glycosides inoonekwa sechimiro uye bioactive

TCM tsananguro

Yin: "Yin" nderimwe remasimba maviri anopindirana anopesana echisikigo, maererano neChinese yekare kuvakwa kwepasirese. "Yin" inoratidzwa seinononoka, yakapfava, inobereka, inopararira, inotonhora, inonyorova kana yakadzikama, uye inosanganiswa nemvura, pasi, mwedzi, chikadzi uye husiku.

Qi: Mukutaura kwe acupuncture, "qi" ndiyo "simba rehupenyu". Ndiyo sosi yekufamba kwese mukati memuviri, dziviriro kubva pakupinda kwemuviri, sosi yezvese metabolic chiitiko, inopa kubatwa kwematishu.

Kutenda

Iri basa rakatsigirwa neBeijing Joint Project yeScience Research ine postgraduate dzidzo-Kiyi yekutsvagisa tekinoroji uye mashandisiro ekuchengetedzwa kwekuongorora kwezvinhu zvine chepfu zveChina zvemishonga zvichibva pakuumbwa kwemakemikari uye hunhu hwezebrafish.

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Min.Order Quantity:100 Piece/Zvimedu

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Ethnopharmacological relevance

Forsythiae Fructus (inonzi Lianqiao muchiChinese), muchero weForsythia suspensa(Thunb.) Vahl, inoshandiswa semushonga wakajairika muChina, Japan neKorea. Inoshandiswa kurapa pyrexia, kuzvimba,gonorrhea,carbuncleuyeerysipelas. Zvichienderana nenguva yekukohwa yakasiyana, Forsythiae Fructus inogona kuiswa muzvikamu zviviri zvinoti Qingqiao neLaoqiao. Michero yegirinhi inotanga kuibva inounganidzwa seQingqiao, nepo yero yanyatsoibva inounganidzwa seLaoqiao. Zvose zvinoshandiswa pakushandiswa kwekurapa. Ongororo iyi ine chinangwa chekupa pfupiso yakarongeka yeF. suspensa(Forsythia suspensa(Thunb.) Vahl) uye kuratidza kuwirirana pakati pemashandisirwo echinyakare uyePharmacological mabasakuitira kupa kurudziro yetsvagurudzo yeramangwana.

Zvishandiso uye nzira

Zvese zvinoenderana neruzivo nezveF. suspensayakatsvakwa naScifinder uye yakawanikwa kubva mudura resainzi rinosanganisira Springer, Science Direct, Wiley, Pubmed neChina Knowledge Resource Integrated (CNKI). Zvinyorwa zvemunzvimbomo nemabhuku zvakasechwa zvakare.

Results

Zvinoenderana neyakajairwa Chinese herbal zvinyorwa uye Chinese Pharmacopoeia, Forsythiae Fructus inonyanya kuratidza kupisa-kuchenesa uye detoxifying mhedzisiro muTCMprescriptions. Mukutsvakurudza kwemazuva ano, anopfuura 230 makomisheni akaparadzaniswa uye akaonekwa kubvaF. suspensa. 211 Pakati pavo vakaparadzaniswa nemichero.Lignansuye phenylethanoidglycosidesinoonekwa seyakajairika uye inoshanda zvinoumba mushonga uyu, senge forsythiaside, phillyrin,rutinuye phillygenin. Vakaratidza anti-inflammatory, antioxidant, antibacterial, anti-virus, anti-cancer uye anti-allergy effects,etc.Parizvino, hapana mushumo wehupfu hweForsythiae Fructus, kunyangwe kuchetura kudiki kweforsythiaside kunotaurwa muzvinyorwa zvemuno. Kuenzaniswa neLaoqiao, Qingqiao ine mazinga epamusoro eforsythiaside, forsythoside C, cornoside,rutin, phillyrin,gallic aciduyechlorogenic aciduye yakaderera mazinga e rengyol,β-glucose uye S-suspensasidemethyl ether.

Mhedziso

Kupisa-kuchenesa zviito zveForsythiae Fructus zvakavakirwa pane anti-inflammatory uye antioxidant zvimiro zve lignans uye phenylethanoid.glycosides. Detoxifying mhedzisiro inoenderana neiyo antibacterial, antiviral uye anti-kenza zviitiko zveForsythiae Fructus. Uye zvechivanhu Chinese mushonga (TCM) maitiro eForsythiae Fructus (inovava flavour, kutonhora zvishoma uye lung meridian) yakatsigira yayo yakasimba anti-kuzvimba mhedzisiro. Mukuwedzera, iyo inoshamisa anti-inflammatory uyeantioxidant masimbayeForsythiae Fructus inobatsira kune yayo inopesana negomarara uyeneuroprotectivemabasa. Iyo yakakwira chikamu che lignans uye phenylethanoid glycosides muQingqiao kupfuura Laoqiao inogona kutsanangura zviri nani antioxidant kugona kweQingqiao uye kakawanda kushandiswa kweQingqiao mu.TCMprescriptions. Zvekutsvagisa ramangwana, zvakawandain vivokuyedza uye zvidzidzo zvekiriniki zvinokurudzirwa kuti zviwedzere kujekesa hukama pakati pemashandisirwo echinyakare nemashandisirwo azvino. Kana zviri zveQingqiao neLaoqiao, zvinoramba zvichisiyaniswa nemaitiro ese-kutenderera ekudzora mhando, uye maumbirwo emakemikari nemhedzisiro yekiriniki pakati pavo inofanira kuenzaniswa.