Wholesale Yakachena Natural Atractylodes Lancea Mafuta eZuva Remazuva Chemakemikari Indasitiri Herb Extract Atractylis Oil

pisthorchis viverrini (OV) -induced cholangiocarcinoma (CCA) ndiyo gomarara rakajairika pakati pemurume nemukadzi, kunyanya muThailand. Ongororo ichangoburwa yakaratidza kuti iyo ethanol yakatorwa yeAL yakaita inhibitory mhedzisiro paOV-induced CCA yemhuka modhi pasina huturu huri pachena kuburikidza nemuromo wekutonga kwemazuva makumi matatu zvichienderana nemhedzisiro kubva ku positron emission tomography-computed tomography uye murume wechiSyria hamsters [7]. Kuti uongorore mhedzisiro yeAL rhizome pane gastrointestinal motility, iyo atropine-, dopamine-, uye 5-hydroxytryptamine (5-HT)-inorapwa mbeva dzakagamuchirwa muchidzidzo. Mhedzisiro yacho yakaratidza kuti 1 mg/kg inobvisa inogona kudzvanya dopamine-induced gastric kubuda uye gastrointestinal motility inodzikira kuburikidza nejekiseni remukati. Iyo inotorwa pahuwandu hwe1000 mg / kg inogona kudzikamisa atropine-induced intestinal motility kuderera, uye iyo yakabudiswa ye500 mg / kg dose inogona kuvhara 5-HT-induced gastric kubuda uye kuderera kwemukati mudumbu kuderera [8]. Uyezve, AL yakashandisa anti-gastric ulcer effect mumuenzaniso wemakonzo kuburikidza nekuderera kwevarevereri vanopisa (kureva tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), IL-6), uye prostaglandin E2 (PGE2) uye kuwedzera epidermal growth factor (EGF) uye trefoil factor2 (TFF2) [9]. Zvirwere zvefungal zvinokonzerwa nevhu zvakaderedza goho renzungu ne30% [10]. Munguva pfupi yadarika, zvakanzi kudyidzana nenzungu, AL inogona zvakare kudzvanya zvirwere zvefungal zvinotakura ivhu kuburikidza nekudzivirirwa kweFusarium oxysporumkukura [11]. Petroleum ether (PE) kutorwa kubva kuAL kwakaratidza inhibitory mhedzisiro paBGC-823 uye SGC-7901 masero egomarara remudumbu. Chikamu chePE chinogona kukonzera apoptosis, kusungwa kwesero kutenderera, uye mitochondrial transmembrane inogona kuchinja [12]. Mushumo wechangobva kuitika wakaratidza kuti MeOH yakabudiswa ye AL inogona kudzivisa nitric oxide (NO) kugadzirwa mu lipopolysaccharide-inosimudzira murine macrophage-yakafanana neRAW264.7 masero uye inokonzera granulocyte-colony stimulating factor (G-CSF) secretion mumurine normal colonic epithelial MCE301 masero. NO is a free radical [13]. Iyo ethanol yakatorwa yeAL yakaita zvakakosha inhibitory effect pa lipase ne IC50 9.06 µg/mL mumunhu pancreatic lipase assay, uye yakaratidza anti-obesity effect pa-high-fat diet-induced obesity mice model pakukwirira kwe500 mg. /kg [14]. Zvinyorwa zvemvura kubva kuAL zvakaratidza basa rinopesana ne serotonin receptors uye inhibitory mhedzisiro pane yakasarudzika 5-HT2A/2C agonist 1-(2,5-dimethoxy-4-iodophenyl) -2-aminopropane-induced musoro-twitch mhinduro mumakonzo. [15]. Zvinyorwa zvemvura kubva kuAL zvakaderedza triptolide-induced toxicity kuburikidza ne-down-regulation yehepatic expression yeCYP3A. Munguva iyi, AL inogona kuvandudza anti-inflammatory effects ye triptolide. Izvi zvakawanikwa zvakaratidza kuti AL inogona kuvharidzira chepfu uye kuwedzera kurapa kwe triptolide kuburikidza nemusanganiswa.